Mangosteenpeel has benefit as an antioxidant

Mangosteenpeel has benefit as an antioxidant, as well as an antibacterial. Compounds that have antibacterial activity is α-mangostin. In order to make it easy the used and effectiveness of antibacterial, mangosteenpeel extract needs to made as ointments. This study purpose to determine the effect of the combination of PEG 400 and PEG 4000 base on the physical characteristic and antibacterial against  Staphylococcus aureus as well as get the optimum formula. Ointments were made into four formulas that have low level 26 g and high level 32 g of PEG 400, low level 30 g and high level 37 g of PEG 4000 with factorial design method. Formula optimization using Design Expert software with the parameters of  the physical characteristic of ointment and antibacterial activity. Factorial design predicted results verifie and analyzed byt-test LSD with 95% confidence level. The optimum combination of PEG 400 and PEG 4000 incomparison of 30,7g and 33g in 100g of ointment. Comparison of prediction and verification showed significant differences in testing parameters pHand not significantly different in dispersive power, adhesion, viscosity and antibacterial. Optimal ointment with a semi-solidform, pH 4,17, viscosity 98,33d.Pas, adhesion 17,33seconds, dispersive power10,36 cm2 and inhibition zone diameter of 11 mm